Chinese Journal of Endemiology 2000;19(4):262-3
(As cited and abstracted in Fluoride 2001; 34(1):80)
Effects of high fluoride drinking water on the cerebral functions of mice
Sun Z-R, Liu F-Z, Wu L-N, et al.
For Correspondence: Department of Environmental Health, Tianjin Medical University, Tianjin 300070, China.
Objective: To study the effects of high fluoride concentration in drinking water on the cerebral functions of mice. Methods: Learning and memory abilities of high-fluoride exposed and control groups of mice were measured by behavior-toxicological test (Shuttle box Test), and the cholinesterase (ChE) activity in brain tissue homogenate of the mice was determined. Results: Learning and memory abilities of high-fluoride exposed groups were significantly lower than that of the control group, while the brain ChE activities of high-fluoride exposed groups were significantly higher. Conclusions: High fluoride concentration in drinking water can decrease the cerebral functions of mice. Fluoride is a neurotoxicant.
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