Fluoride 1981; 14 (3): 132-141

Effect of fluoride on tissue enzyme activities in rat: Biochemical and histochemical studies.

Singh M, Kanwar KS.

Department of Biophysics, Panjab University, Chandigarh, India.

Activities of various enzymes were determined biochemically and histochemically in the liver and kidney of rats subjected for 10 mo. to fluoride (F-) concentrations of 0 (control), 10 (group 1) and 25 ppm (group 2) in drinking water. The activity of alkaline phosphatase, acid phosphatase and succinic dehydrogenase decreased. ATPase activity increased in liver and kidney of group 2 (25 ppm) animals. Lactic dehydrogenase activity also decreased but only in the kidney histochemically. Alterations in enzyme activities were pronounced in proximal and distal convoluted tubules of the kidney. Glutamic oxalacetic transaminase increased slightly in the liver in group 2. F- interfered with intracellular metabolism in liver and kidney. (Abstract from TOXNET)

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