Fluoride 1988; 21(3):127-130.

Biochemical effects of fluoride on thyroid gland during experimental fluorosis

Shashi A

Department of Zoology, Punjabi University, Patiala, India.

Summary: Fluorosis leads to fat accumulation in the thyroid gland, hyperlipidemia and hypertriglyceridemia. The administration of sodium fluroide in the concentrations of 5, 10, 20 and 50 mg/kg b.w./day to normal rabbits for 100 days increased the lipid components, total lipids and triglycerides in thyroid gland. The increase in content was highly siginificant compared to controls. The level of free fatty acids was significantly reduced in thyroid gland of fluroide-treated rabbits.


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