Caryologia 1987; 40:79-87.

Genotoxic effect of an environmental pollutant, sodium fluoride, in mammalian in vivo test system.

Pati PC, Bhunya SP.

Laboratory of Genetic Toxicology, P.G. Department of Zoology, Utkal University, Vani Vihar, Bhubaneswar-751 004, India.

SUMMARY - Genotoxicity of Sodium fluoride was evaluated in mice in vivo with the help of different cytogenetic assays. The frequency of chromosome aberration was dose - and time - dependent but not exactly route-dependent. Fractionated dosing induced less aberration. Incidence of micronucleus and sperm abnormality increased with dose. Relative sensitivity of the three
assays has been found to be: Sperm abnormality > Chromosome aberration > Micronucleus. The present results have revealed the mutagenic property of NaF.

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