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Journal of the American Medical Association 1972; 222(7):783-5

Renal failure and fluorosis.

Juncos LI, Donadio JV Jr.

From the Mayo Graduate School of Medicine (University of Minnesota), Resident in Nephrology (Dr. Juncos), and the Division of Nephrology and Internal Medicine, Mayo Clinic and Mayo Foundation (Dr. Donadio), Rochester, Minn.

Abstract: Two patients had a combination of renal insufficiency and systemic fluorosis. One had bilateral vesicoureteral reflux and recurrent pyelonephritis, with resulting renal atrophy; the other had probable renal dysgenesis of indeterminate origin. Both patients had polydipsia, polyuria, and markedly reduced renal function. Both also had clinical and roentgenographic evidence of systemic fluorosis. It is postulated that the renal insufficiency which resulted in the large intake of fluoride-containing water and reduced excretion of fluoride combined to produce systemic fluorosis.

PMID: 4677926 [PubMed - indexed for MEDLINE]

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