Archives of Environmental Health 1974; 29: 230-235

Sodium fluoride as potential mutagen in mammalian eggs

Georgiana Jagiello & Ja-Shein Lin

From the Departments of Obstetrics & Gynecology and Human Genetics & Development; and the International Institute for the Study of Human Reproduction, Columbia University College of Physicians & Surgeons, New York.

Abstract: Evidence from other forms demonstrating mitotic chromosome damage has suggested that sodium fluoride (NaF), a primary air pollutant, be explored as a mutagenic compound in female mammalian germ cells. In vitro experiments with mouse, sheep, and cow oocytes have disclosed a low incidence of anaphase lags, suppression of polar body I, and fragmentation and rearrangement. In vivo experiments showed only a minor effect on oocyte meiotic maturation, but species' variations of sensitivity to NaF would suggest further investigations of progeny of the ewe and cow in contaminated areas.

Return to Fluoride Bibliography