Excerpt from:

Desai VK, et al. (1993). Epidemiological study of goitre in endemic fluorosis district of Gujarat. Fluoride. 26:187-90.

"We examined 22,276 individuals for  presence of goitre and dental fluorosis and estimated the fluoride and iodine content of their drinking water. Overall goitre and dental fluorosis prevalences were 14.0% and 12.2%, respectively, and were significantly and positively correlated. No significant relationship was observed between water iodine level and goitre. In the study area only 0.3% of cases were visible goitre (Grade-II and above) and all goitre cases were euthyroid. This suggests that fluoride-induced goitres are brought about by anatomical or structural changes rather than functional changes."

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