Fluoride 1997; 30(1): 51-58.

Toxicity of fluoride to diabetic rats

C A Y Banu Priya, K Anitha, E Murali Mohan, K S Pillai* and P B Murthy

Department of Toxicology, Fredrick Institute of Plant Protection and Toxicology, Padappai 601301, Chengai Anna District, Tamil Nadu, India.

SUMMARY: Wistar rats were given 20 ppm fluoride in drinking water, or single administration of 115 mg/kg alloxan i.m. to induce diabetes, or single administration of 115 mg/kg alloxan i.m. followed by 20 ppm fluoride for 31 days. Blood sugar level increased in rats given alloxan and alloxan + fluoride. Body weight gain in rats given alloxan + fluoride decreased significantly compared to other groups. Decrease in haemoglobin and glutamic oxaloacetate transaminase (GOT) was seen only in rats given alloxan + fluoride. In this group alkaline phosphatase, the target enzyme in fluoride toxicosis, increased considerably. The toxicity of fluoride in diabetic rats was further reflected in organ weight data. This investigation shows that fluoride toxicity is greater in diabetic rats.

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